Page 13 - LabMedya - ENG - 07

www.labmedya.com | SPECIAL EDITION 7

YOUR DAILY DOSE OF SCIENCE 13

throughout the genome explore. The researchers can be rejuvenated without group leader in the Epige- of aging. This approach
indicate age. The second is speculate that key areas losing their function and netics research program holds promise for valuable
the transcriptome, all the of the genome involved in that rejuvenation looks who has recently moved discoveries that could open
gene readouts produced shaping cell identity might to restore some function to lead the Altos Labs up an amazing therapeutic
by the cell. By these two escape the reprogramming to old cells. The fact that Cambridge Institute, said: horizon.”
measures, the repro- process. we also saw a reverse of “This work has very exciting
grammed cells matched aging indicators in genes implications. Eventually, Reference: “Multi-omic
the profile of cells that were Diljeet concluded: “Our associated with diseases we may be able to identify rejuvenation of human
30 years younger com- results represent a big step is particularly promising for genes that rejuvenate cells by maturation phase
pared to reference data forward in our understand- the future of this work.” without reprogramming, transient reprogramming”
sets. ing of cell reprogramming. and specifically target 7 April 2022, eLife.
We have proved that cells Professor Wolf Reik, a those to reduce the effects
The potential applica-
tions of this technique are
dependent on the cells not
only appearing younger, WE'D LIKE TO BE YOUR
but functioning like young
cells too. Fibroblasts SOLUTION PARTNER FOR
produce collagen, a mol- THE HEATING PROCESSES
ecule found in bones, skin
tendons and ligaments, IN YOUR LABORATORY.
helping provide structure
to tissues and heal wounds. Protherm is with you to offer solutions
The rejuvenated fibroblasts for your special heat treatment
produced more collagen requirements and analyses.
proteins compared to
control cells that did not
undergo the reprogram-
ming process. Fibroblasts
also move into areas that
need repairing. Research-
ers tested the partially
rejuvenated cells by
creating an artificial cut in a
layer of cells in a dish. They
found that their treated
fibroblasts moved into the >Atmosphere Controlled furnaces up to 2.000°C
gap faster than older cells. >Ovens up to 650°C
This is a promising sign > High Temperature Furnaces up to 1.800°C
>High Temperature Tube Furnaces up to 1.800°C
that one day this research >Split Furnaces and CVD systems up to 1.500°C
could eventually be used to >Rotary Furnaces up to 1.600°C
create cells that are better >Vacuum Furnaces up to 1.500°C and 10-3 Torr
>And more…
at healing wounds.

In the future, this research
may also open up other
therapeutic possibilities;
the researchers observed
that their method also had
an effect on other genes
linked to age-related dis-
eases and symptoms. The
APBA2 gene, associated
with Alzheimer’s disease,
and the MAF gene with a
role in the development of
cataracts, both showed
changes towards youthful RTR Series PLF Series PVAC Series ACF Series 2.000°C
levels of transcription. Rotary Furnaces Chamber Furnaces Vacuum Furnaces Atmosphere Controlled
Furnaces
The mechanism behind
the successful transient
reprogramming is not yet Ergazi Mah. 1695. Cad. t: +90 312 257 13 31 www.prothermfurnaces.com
fully understood, and is the 1819. Sok. No:5 f: +90 312 257 13 35 mail@prothermfurnaces.com
next piece of the puzzle to Batıkent 06370 Ankara