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        18                                                                                HEALTH AND LABORATORY MAGAZINE
























        MIT ENGINEERS DEVELOP

        STICKERS THAT CAN SEE

        INSIDE THE BODY




        New stamp-sized ultrasound adhesives produce clear
        images of heart, lungs, and other internal organs.



        Ultrasound imaging is    maintained a strong adhe-  images on demand,” says   ble array of tiny ultrasound   layers of elastomer that
        a safe and noninvasive   sion and captured changes   the study’s senior author,   transducers, the idea being   encapsulate a middle layer
        window into the body’s   in underlying organs as   Xuanhe Zhao, professor   that such a device would   of solid hydrogel, a mostly
        workings, providing clini-  volunteers performed   of mechanical engineering   stretch and conform with a   water-based material that
        cians with live images of a   various activities, including   and civil and environmental   patient’s body.  easily transmits sound
        patient’s internal organs.   sitting, standing, jogging,   engineering at MIT. “We                  waves. Unlike traditional
        To capture these images,   and biking.            believe we’ve opened a   But these experimental   ultrasound gels, the MIT
        trained technicians ma-                           new era of wearable imag-  designs have produced   team’s hydrogel is elastic
        nipulate ultrasound wands   The current design requires   ing: With a few patches on   low-resolution images, in   and stretchy.
        and probes to direct sound   connecting the stickers to   your body, you could see   part due to their stretch:
        waves into the body. These   instruments that trans-  your internal organs.”  In moving with the body,   “The elastomer prevents
        waves reflect back out to   late the reflected sound                       transducers shift location   dehydration of hydrogel,”
        produce high-resolution   waves into images. The   A STICKY ISSUE          relative to each other, dis-  says Chen, an MIT post-
        images of a patient’s heart,   researchers point out that                  torting the resulting image.  doc. “Only when hydrogel
        lungs, and other deep    even in their current form,   To image with ultrasound,                    is highly hydrated can
        organs.                  the stickers could have   a technician first applies   “Wearable ultrasound im-  acoustic waves pene-
                                 immediate applications:   a liquid gel to a patient’s   aging tool would have huge   trate effectively and give
        Currently, ultrasound imag-  For instance, the devic-  skin, which acts to transmit   potential in the future of   high-resolution imaging of
        ing requires bulky and spe-  es could be applied to   ultrasound waves. A probe,   clinical diagnosis. However,   internal organs.”
        cialized equipment avail-  patients in the hospital,   or transducer, is then   the resolution and imaging
        able only in hospitals and   similar to heart-monitoring   pressed against the gel,   duration of existing ultra-  The bottom elastomer
        doctor’s offices. But a new   EKG stickers, and could   sending sound waves into   sound patches is relatively   layer is designed to stick
        design by MIT engineers   continuously image internal   the body that echo off in-  low, and they cannot image   to skin, while the top layer
        might make the technology   organs without requiring a   ternal structures and back   deep organs,” says Chong-  adheres to a rigid array
        as wearable and accessi-  technician to hold a probe   to the probe, where the   he Wang, who is an MIT   of transducers that the
        ble as buying Band-Aids at   in place for long periods of   echoed signals are trans-  graduate student.  team also designed and
        the pharmacy.            time.                    lated into visual images.                         fabricated. The entire ul-
                                                                                   AN INSIDE LOOK           trasound sticker measures
        In a paper appearing today   If the devices can be made   For patients who require                  about 2 square centime-
        in Science, the engineers   to operate wirelessly — a   long periods of imag-  The MIT team’s new ultra-  ters across, and 3 millime-
        present the design for a   goal the team is currently   ing, some hospitals offer   sound sticker produces   ters thick — about the area
        new ultrasound sticker — a   working toward — the ul-  probes affixed to robot-  higher resolution images   of a postage stamp.
        stamp-sized device that   trasound stickers could be   ic arms that can hold a   over a longer duration by
        sticks to skin and can pro-  made into wearable imag-  transducer in place without   pairing a stretchy adhesive   The researchers ran the
        vide continuous ultrasound   ing products that patients   tiring, but the liquid ultra-  layer with a rigid array of   ultrasound sticker through
        imaging of internal organs   could take home from a   sound gel flows away and   transducers. “This combi-  a battery of tests with
        for 48 hours.            doctor’s office or even buy   dries out over time, inter-  nation enables the device   healthy volunteers, who
                                 at a pharmacy.           rupting long-term imaging.  to conform to the skin while   wore the stickers on vari-
        The researchers applied                                                    maintaining the relative   ous parts of their bodies,
        the stickers to volunteers   “We envision a few patch-  In recent years, research-  location of transducers to   including the neck, chest,
        and showed the devices   es adhered to different   ers have explored designs   generate clearer and more   abdomen, and arms. The
        produced live, high-resolu-  locations on the body,   for stretchable ultrasound   precise images.” Wang   stickers stayed attached
        tion images of major blood   and the patches would   probes that would pro-  says.                  to their skin, and produced
        vessels and deeper organs   communicate with your   vide portable, low-profile                      clear images of under-
        such as the heart, lungs,   cellphone, where AI algo-  imaging of internal organs.   The device’s adhesive   lying structures for up to
        and stomach. The stickers   rithms would analyze the   These designs gave a flexi-  layer is made from two thin   48 hours. During this time,
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