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       YOUR DAILY DOSE OF SCIENCE                                                                                              019




       Cancer treatment with    gy as the golden year espe-  provides a service where   Our prototype plan is ready   sources.
       genetically modified CAR-T   cially for the opening of the   the digital data that needs   for DNA production, storage
       cells has been on the    genetic treatment era. After   to be stored for long years   and practical back reading,   You have encrypted the
       agenda of the world for   that year, pharmaceutical   is encrypted by storing it in   however investment is   first string of the Turkish
       the last few years.  When it   companies have tried to   DNA libraries and archived   required.  We can store our   National Anthem, following
       appeared in US with a price   produce genetic regulation   with the algorithm we   DNA archives we produce   the sequences of the
       of $475,000, everyone was   methods (CRISPR) or gene   produce with DNA-cryp-  on the HiDNA platform with   Turkish alphabet's DNA
       looking for a way to afford   transfer methods in the   tology approach to get   chemical formulations that   letters (A, T, C & G).  A
       it. European countries have   treatment of many genetic   them secure. The HiDNA   can store the DNAs without   software is also developed
       been working for many    diseases considered incura-  data archive will not require   requiring special ambient   for this.  You are guiding
       years to produce this meth-  ble.  In other words, it seems   additional costs such as   conditions and at room   not only to present ideas
       od in their countries.  We,   that we will be hearing a lot   electricity, cold room and   temperature for up to 40   to your environment but
       as Turkey and Acıbadem   about the people whose    maintenance-repair that   years.                   also to turn that idea into
       Labcell Laboratory, started   lives are changed with ge-  would be required for long                  a business plan and sales.
       this study with the initiative   netic treatments in the next   years for the storage of per-  You transfer samples of   What is your current goal?
       of Prof. Dr. Ercüment Ovalı.   years.              sonal data, account infor-  DNA data storage systems
       To perform this treatment,                         mation and health records   in a clear language. You   We aim to be a pioneer in
       we had to conduct long   For many centuries, many   on silicone chips. For this   have prepared an article   the development of DNA
       laboratory and animal trials.   people had to live with   reason, the HiDNA project,   titled “It Is Possible to   data storage and DNA-
       Genetic design, lentivirus   incurable genetic diseases.    which integrates molecular   Store 200 Million GB Digital   based computers by 2023
       production and CAR-T cell   However, “Rare Diseases”   DNA biology with computer   Data in 1 Gram DNA!”.   as a domestic initiative.  We
       production had never been   started being treated with   algorithms, offers a platform   We published it in the last   aim to provide technology
       performed in our country   CRISPR and other Gene   that combines effective   issue. You mentioned that   transfer and added value
       before in clinical standards.   Therapy methods in the last   encryption-storage and   the usage areas of the   in synthetic DNA biology to
       For this reason, we started   decade.  You have recently   practical read-back units   data storage in DNA have   our country as an innovative
       everything from scratch.  We   held the CRISPR genome   where privacy is prioritized.   increased considerably with   technology in archiving
       have successfully completed   modification technology                        the developing technology.    digital data, in order to
       our laboratory and animal   workshop, which has    “HiDNA” Platform technolo-  It seems it will continue   store text, visual, audio and
       trials over the past three   revolutionized Genetic   gy for Encrypting, Archiving   increasing.  What would you   account data in DNA safely
       years and we are now about   Engineering in this regard.   and Practical Readback of   say about it?   and in the smallest medium
       to publish the scientific   What did you discuss there?   Digital Data in DNA is the                  for many years.  In addition
       paper.  In early 2019, we                          first and only in our country.    In health services, a lot   to extending the archiving
       successfully got our permis-  We strive to hold our CRIS-  The team that formed our   of data is produced from   effectiveness of digital data
       sions from the Ministry of   PR workshops in different   initiative is comprised of   many sources. Similarly, in   in DNA to hundreds of years,
       Health and the human ethics   cities or universities every   people experienced DNA   the field of health, signifi-  we also aim to be a pioneer
       committee and rolled up our   year. Our goal is to increase   techniques and algorithm   cant amounts of data are   in the field of health by using
       sleeves for clinical studies.    the number of people who   and code writing. The team   produced in institutions and   the experiences we have
       CAR-T cell therapy requires   know this technique, both in   also closely follows the   organizations of various   gained in this field together
       a fully multidisciplinary   academic research and in   technologies of the future   sizes ranging from a doc-  with the algorithm and
       collaboration.  In addition   the biotechnology industry.    and their market shares.    tor's office to multi-service   genetic production retention
       to the need to have a team   For this purpose, we try to   For this reason, the aim of   polyclinics, health centers   methods we have devel-
       of experts in the laboratory,   share the CRISPR technol-  the HiDNA initiative in the   and large hospital networks.   oped, in gen therapies which
       it is a very important chain   ogy experiences we have   long term with appropriate   However, the huge amounts   is our field of specialization,
       that a team that has worked   acquired abroad. In each   investments and opportuni-  of health-related data   and in producing special
       well is performing this treat-  workshop, we are especially   ties is to predict and get an   made it difficult to process   genetic designs.  We aim
       ment during the application   interested in many of our   effective share in the sector,   by traditional data process-  to provide cost-effective
       and follow-up in the hospital.    friends who have a project   while there is not a market   ing methods. Large Health   technologies (without the
       For this reason, we have   to produce with CRISPR in   share yet, by keeping its   Data includes data based   need for electricity expense
       managed to apply these   mind, and we advise them   patents and infrastructures   on heterogeneous, mul-  or cold storage space as in
       applications clinically with   on how they can achieve   ready until the era of Data   ti-spectral, incomplete and   the computer data storage)
       the gathering of experts   their goals. We also held our   Storage and DNA com-  inaccurate observations (for   with the methods we will
       from different fields and our   CRISPR workshop at İzmir   puter technologies. HiDNA   example, demographic data   develop with HiDNA for the
       applications will increasingly   University of Economics in   consists of web platform   as well as diagnosis, treat-  practical sequencing and ef-
       continue.                October 2019 and we came   and DNA production-stor-  ments, diseases, disease   ficient storage of the human
                                a bit closer to our goal of   age-back-reading stages.   prevention, injury, physical   genome.
       Tens of cellular genetic   reaching everyone.      The prototype of HiDNA.co   and mental disorders)
       therapy trials are carried                         website has been prepared.    generated from different
       out every year in the world.    Although data storage gets   ArabLabChem220x150Yellow_Layout 1  11/12/2019  17:00  Page 1
       You said that more than   cheaper as technology
       30 gene therapy products   evolves, the storage and
       are planned to be on sale in   reliability of big data
       2025. Can the patients, who   requires large costs
       are considered incurable   and systems.  DNA, our     THE MOST POWERFUL
       for years, be treated with   body's main treasure of
       this method?             knowledge, has shaped        ANNUAL SHOW FOR THE                        THE WORLD OF
                                the bioindustry to store                                                SCIENCE & CHEMISTRY
       The pharmaceutical compa-  this big data and keep it                                             COME TOGETHER
       ny executives we hosted in   safe for decades without   GLOBAL LABORATORY &
       a course I took in New York   any other expense.  By
       University at the beginning   establishing a team under   ANALYTICAL INDUSTRY
       of 2013 said that although   the name of "HiDNA", you
       they produced drugs for   combined your information   The show that attracts Scientific
       many diseases, they did   in your field with computer   & Laboratory personnel from a wide
       not do any study for some   algorithms and developed   range of global industries including:     2020
       diseases.  When we asked   a personalized DNA data     AGRICULTURE        INSTRUMENTATION
       the reason of that, they   storage method that can     BIOTECHNOLOGY      LABORATORY TECHNOLOGY
       said that there are very few   be stored for many years.     CHEMICALS & REAGENTS     MATERIAL TESTING
                                                              CHEMICAL ENGINEERING
                                                                                 MEASUREMENT & TECHNOLOGY
       people who can buy these   You have a website named     CHEMICAL PROCESSING     MEDICAL RESEARCH
       drugs, that’s who can afford   http://hidna.co/. What can     CONSTRUCTION  ANALYSIS     NANOTECHNOLOGY   16 – 18 MARCH
                                                              DRUG DISCOVERY &
                                                                                 PETROCHEMICALS
       the costs thereof, in Africa   you say about HiDNA?    DEVELOPMENT        PROCESS CONTROL
       or other Middle Eastern                                ENERGY & ENVIRONMENT     QUALITY CONTROL               DUBAI
       countries in case they   “HiDNA” platform technolo-    EQUINE DEVELOPMENT     RESEARCH & DEVELOPMENT
                                                                                 ROBOTICS & AUTOMATION
                                                              FOOD TESTING & DIAGNOSTICS
       produce the drug.  The year   gy for Encrypting, Archiving     FORENSICS & SECURITY       WWW . ARABLAB .COM
       2013 went down in history   and Practical Readback
       thanks to CRISPR technolo-  of Digital Data in DNA,
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